O20: PREOPERATIVE INTRAVENOUS IRON THERAPY AND SURVIVAL AFTER COLORECTAL CANCER SURGERY: LONG TERM RESULTS FROM THE INTRAVENOUS IRON IN COLORECTAL CANCER-ASSOCIATED ANAEMIA (IVICA) TRIAL

Abstract Background Intravenous iron is now the standard treatment to correct preoperative anaemia. However, may promote tumour growth and progression which could influence cancer recurrence survival. We explore long term postoperative outcomes of patients receiving oral (OI) or intravenous (IVI) as part a randomised controlled trial. Method The multicentre IVICA trial anaemic colorectal in 1:1 fashion receive either OI IVI prior their elective operation. Follow up analysis all was performed Kaplan-Meier survival estimates Cox proportional hazard models were used compare groups. A pooled comparing who did/did not achieve resolution anaemia also undertaken. Result, Data available for 106 116 (OI n=55, n=51). Median follow 61 months (IQR 38-68, [range 1-80]). Overall at 3 5 years 82%(95% CI 76-90) 72%(58-83) respectively 75%(61-86) 59%(45-72) IVI, P=0.106. No significant difference 5-year overall (HR 1.73, 95% 0.90-3.34 P=0.102) disease-free 1.50, 0.83-2.73 P=0.182) observed between Those non-anaemic operation demonstrated improved year 3.26 [1.01-10.58], P=0.05). Non-significant trends 2.29 [0.91-5.81], p=0.08) group Conclusion Preoperative correction confers advantage following surgery. Due its superior efficacy recommended choice this Take-home message anaemia, achieved most effectively with iron, offer after